"I stand behind every one of these operations. I was proud to execute them, and I would do it again tomorrow," Hegseth said at a Pentagon briefing, referring to US military operations involving Iran, Yemen and Venezuela.
"And if that regime makes one wrong move, as the president said, we remain locked and loaded with the full weight and lethality of Central Command," he said, referring to Iran.
Hegseth also said American forces had destroyed more than 80% of Iran's nuclear industrial base during the war.
Hegseth says more than 80% of Iran's nuclear industrial base destroyed
Hegseth said American forces had struck more than 13,000 targets during Operation Epic Fury, the US military campaign against Iran, and caused extensive damage to the country's military and nuclear infrastructure.
"In under 40 days of sustained combat, more than 13,000 targets struck. Their navy sunk. Their air force grounded. Their defense industrial base gone. More than 80% of their nuclear industrial base gone," he said.
Hegseth also said the US naval blockade of Iranian ports remained in place and asserted that Washington controlled the Strait of Hormuz.
"The ironclad blockade unbroken. We control the Strait of Hormuz," he said.
"By every measure, we achieved a historic military victory," Hegseth added.
Trump also says he would launch Iran war again
Hegseth's remarks echoed Trump's defense of the decision to attack Iran, despite the president acknowledging that the conflict had contributed to Republican losses in the November 3 midterm elections.
"I did the right thing. I would have done it again," Trump told The Wall Street Journal.
Trump also said the military campaign was necessary to prevent Iran from acquiring nuclear weapons.
"We had no choice. You can't let Iran have a nuclear weapon," he told reporters last Wednesday.
Hegseth discusses strikes on Iranian nuclear facilities
Hegseth also referred to Operation Midnight Hammer, the earlier US strikes involving B-2 bombers against Iran's nuclear facilities at Fordow, Natanz and Isfahan.
"The largest and most successful B-2 strike in American history. Nuclear sites obliterated," he said.
Hegseth reiterated Washington's position that Iran must not acquire nuclear weapons.
"The crazy Islamists in Tehran will never, ever have a nuclear weapon," he said.
He credited Trump with ordering military action that previous administrations had avoided.
"History will judge the Iran war quite differently than conventional wisdom right now," Hegseth said.
"We didn't start this war. Iran did 47 years ago," he added, referring to the 1979 Islamic Revolution.
Hegseth says operations were lawful
The Secretary of War also addressed the legality of the military operations conducted under Trump's administration, including the campaign against Iran.
"Iran, the cartels, Maduro, Yemen, every one was a lawful operation ordered by the commander in chief, then ordered by myself, notified to Congress, and executed by American warriors who did their jobs," he said.
His remarks followed an impeachment effort by Republican Representative Thomas Massie, who accused him of launching military operations without congressional authorization.
Hegseth rejected suggestions that the operations had been unlawful.
"Their service was not a crime. These are heroes, and no politician in Washington will tell them otherwise while I hold this office," he said.
He added that the operations had targeted military capabilities and criminal activities.
"We destroyed terror regimes' capabilities. We sank the boats carrying poison into our communities," Hegseth said.
Hegseth acknowledges 18 US military deaths
Hegseth said 18 American service members had died during Operation Epic Fury.
"Nobody was lost in the mission in Venezuela, but 18 Americans have given their lives in Operation Epic Fury," he said.
"We know their names. I've been to Dover. We honor them every day, but their sacrifice only stiffens our resolve."
He compared the Iran campaign with previous US military conflicts that lasted for years and resulted in thousands of American deaths.
"For generations, my generation fought other Middle Eastern wars that dragged on for years, for decades. We lost thousands, thousands of Americans," he said.
Hegseth said the Iran campaign would not follow the same course.
"This Epic Fury has never been that, and it never will be," he said.
The United States continues to enforce its naval blockade of Iranian ports while diplomatic efforts involving Washington and Tehran remain underway.